Endocrine Abstracts

Background: Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in congenital adrenal hyperplasia (CAH).Objective: To investigate the frequency of adrenal abnormalities and TART in an unselected adult population of CAH due to 21-hydroxylase deficiency (21-OH) and whether adrenal and testicular pathology correlate with disease categories, current hormone levels and treatment.Patient...

The search for eternal youth has created a market for treatments that might affect the process of aging, and testosterone (T) is one of the hormones that have been in focus. It is well accepted that T levels decline with increasing age, although the individual variation is large. Male hypogonadism is characterised by a low serum T level in combination with a diversity of symptoms and signs such as reduced libido and vitality, decreased muscle mass, increased fat mass and depre...

Objective: The aim of this study was to determine genetic, anthropometric and metabolic features in an unselected population of adult Norwegian patients with classical 21-hydroxylase deficiency (21OHD).Patients,Methods, and design: Sixty-four 21OHD-patients participated (23 men, 41 women; mean age 40.3 (range 19–72) in a cross-sectional study including DNA sequencing of the CYP21A1P-CYP21A2 locus, anthropometric measurements i...

Background: In many acromegalics neurosurgery is unable to control GH secretion while it may harm the normal pituitary.Objective: To investigate the effect of pre-treatment with octreotide on surgical outcome in acromegaly.Methods: Previously untreated acromegalics were randomised directly to surgery or octreotide for six month before transsphenoidal surgery. Three months postoperatively patients underwent OGTT and Insulin Toleranc...